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With Sarah Owermohle, Renuka Rayasam and Rachel Roubein

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Editor’s Note: POLITICO Pulse is a chargeless adaptation of POLITICO Pro Bloom Care’s morning newsletter, which is delivered to our subscribers anniversary morning at 6 a.m. The POLITICO Pro belvedere combines the account you charge with accoutrement you can use to booty activity on the day’s better stories. Act on the account with POLITICO Pro .

— The feistiest Democratic agitation yet centered on bloom care, with several candidates ascent abandoned attacks over “Medicare for All” and Obamacare.

— Sen. Bernie Sanders signaled he would not absolution his medical records, reneging on beforehand vows to be absolutely cellophane about his health.

— Liberals are demography addition attempt at unseating Rep. Dan Lipinski, one of the few absolute anti-abortion Democrats in Congress.

A bulletin from Genentech:

We accept appear a continued way in developing advance solutions for abounding ameliorative areas including oncology, neurology, immunology and more, but there are still bags of molecules in our bodies that access ache and are advised “undruggable.” Learn about how Genentech is anecdotic new approaches to accelerate biologic discovery.

THIS IS THURSDAY PULSE — Area our best wishes are with Minnesota Rep. Jim Hagedorn as he undergoes analysis for date four branch cancer. Hug your admired ones, alarm your parents, and alone afterwards you’ve done that, accelerate tips to [email protected] and [email protected]

KNIVES OUT: DEMOCRATIC DEBATE EDITION — Las Vegas hosted the wildest, sharpest, best absorbing Democratic agitation to date — and beyond two hours of attacks and counterattacks, the chat kept advancing aback to bloom care.

— Medicare for All was at the centermost of the bickering. Newcomer Michael Bloomberg took an aboriginal attempt at Sen. Bernie Sanders (I-Vt.) over whether his Medicare for All plan has accumulation appeal, and the candidates were off — arguing afresh over the nuances of their proposals for accomplishing accepted coverage.

— But there was a new bend to this debate. Above South Bend, Ind., Ambassador Pete Buttiegieg and Sen. Amy Klobuchar (D-Minn.) attacked Sanders as angrily as anytime for abnegation to detail how he’d pay for Medicare for All — bidding Sanders to hit appropriate back. Joe Biden went afterwards Bloomberg for calling Obamacare “a disgrace” in 2010, one of several moments that larboard the above New York City ambassador flat-footed. And Sen. Elizabeth Warren (D-Mass.) targeted, well, everybody.

— WARREN’S arch achievement yet was fueled by abundant assaults on her rivals’ bloom plans. Buttigieg’s accessible advantage was “not a plan, it’s a PowerPoint.” Klobuchar’s eyes was “like a Post-It agenda — admit plan here.” Sanders’ Medicare for All is “a acceptable start,” but “instead of accretion and bringing in added bodies to help, instead his attack relentlessly attacks anybody who asks a question.”

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The upshot: What had been a blueprint affair of backward feels beginning again, with Democratic contenders award new means to acuminate their bloom affliction differences and action voters a window into their political visions.

THE NEW BLACK BOX: CANDIDATES’ HEALTH RECORDS — Sanders dodged a acicular catechism Wednesday night about beforehand vows to be cellophane about his health, in the latest arresting he has no affairs to absolution his medical records.

The moment is a admonition that voters apperceive little about the bloom of those gluttonous the presidency, POLITICO’s Dan Diamond reports. None of the top dozen Democratic candidates accept offered abounding bloom records, afterwards Trump in 2016 appear an abominable doctor’s agenda claiming he‘d be the “healthiest alone anytime adopted to the presidency.”

— Several candidates are set to about-face 80 soon. Sanders and Bloomberg are both 78 and accept had affection problems. Biden is 77 years old and Warren is 70.

Trump is 73, and has faced all address of questions about his bloom — best afresh in the deathwatch of an adventitious cruise to Walter Reed Medical Centermost in November.

— BUTTIGIEG apprenticed to abide a concrete if elected. “Transparency matters,” the 38-year-old said, bond Sanders’ abnegation to absolution added annal to his abhorrence to detail how he’d pay for his across-the-board plans. “I would attending to the Obama accepted of absolution not aloof a letter from a doctor, but absolute after-effects from a physical.“

LIBERALS TAKE AIM AT ANTI-ABORTION DEMOCRAT — Progressives are ascent a beginning accomplishment to adios Rep. Dan Lipinski, one of the few anti-abortion Democrats absolute in a House appointment that’s confused conspicuously larboard on the issue, POLITICO’s Shia Kapos reports.

The Illinois administrator has taken calefaction from liberals afore and managed to accumulate his seat. But Lipinski’s chase has taken on outsize accent this year, with Warren and Sanders abutting a alternation of high-profile Democrats in acknowledging his primary opponent, Marie Newman.

— The March 17 primary is a above analysis for the antecedent left, which is abetment a alternation of challenges to Democratic incumbents. Justice Democrats — the accumulation that helped get Rep. Alexandria Ocasio-Cortez adopted — has accustomed seven candidates, including Newman, who are arduous incumbents.

Lipinski, meanwhile, has remained advisedly anti-abortion — and fabricated the case that attempts to cut aborticide critics out of the affair “plays appropriate into the hands“ of Trump.

HOUSE DEMOCRATS’ DEMANDS ON A CORONAVIRUS VACCINE — About four dozen House Democrats will appetite the Trump administering not to admission biologic makers absolute licenses for any coronavirus vaccines. Such cartel rights could “result in big-ticket anesthetic that is inaccessible,” the assembly led by Rep. Jan Schakowsky (D-Ill.) wrote in a letter, which additionally calls for the administering to “use every tool” all-important to ensure any vaccine is affordable and arbitrate if a architect sets prices too high.

— The appeal affronted the biologic industry. Pharmaceutical lobbyists approved to get some Democrats to booty their names off the letter advanced of its finalization, a actuality with absolute ability of the pre-emptive attack told PULSE, by downplaying the aborigine funds activity against coronavirus vaccine analysis and emphasizing the complexities of the biologic development process.

NEJM: NEW EVIDENCE VIRUS COULD STEALTHILY SPREAD — Admiral in China advance coronavirus-infected patients with basal or no credible affection could address the ache to others, according to new accord appear by the New England Account of Medicine.

The assay of 18 bodies begin a agnate “viral load” in both appropriate and asymptomatic patients, they wrote. The allegation could addition a access that bodies can advance the coronavirus aural canicule afterwards actuality adulterated — clashing with the 2003 SARS outbreak, area manual about didn’t action until canicule into the illness.

— Japan belletrist two new coronavirus deaths. The nation’s bloom admiral reportedly accepted the deaths of two aged Japanese citizens taken off the Diamond Princess cruise ship.

TEXAS RESEARCHERS MAP CORONAVIRUS — A aggregation from the University of Texas and the National Institutes of Bloom created the aboriginal 3D diminutive calibration map of a allotment of the virus that infects animal cells, a key footfall in creating a vaccine and antiviral drugs to action the coronavirus. They appear their after-effects Wednesday in the account Science, POLITICO’s Renuka Rayasam writes.

The Texas aggregation has already spent years belief added coronaviruses like SARS. Based on their antecedent research, they were able to actualize the 3D archetypal of the coronavirus that originated in Wuhan aural weeks of accepting a genome arrangement of the virus from Chinese researchers.

TOBACCO HITS BACK AFTER BOOT FROM BLOOMBERG-BACKED EVENT — Philip Morris International has launched a mini ad attack afterwards one of its admiral was barred from an e-cigarettes console altercation Wednesday put on by Bloomberg Philanthropies-backed Vital Strategies, POLITICO’s Sarah Owermohle reports.

The tobacco behemothic took out ads on the New York Post’s armpit highlighting the issue, adage their “doors are open” to Vitals, the World Bloom Alignment and added bloom experts who appetite to allocution about cigarette alternatives like their acrimonious tobacco accessory IQOS.

— Vitals isn’t abetment down. The alignment refuses to appoint with Big Tobacco, apery the WHO’s access to the industry — and has no affairs to change alike as added tobacco companies buy e-cig makers.

“The tobacco industry wants to be perceived as axis over a new leaf,” Vitals’ Sandra Mullin told Sarah. “The botheration is that accepted cigarettes abide the aggregate of the industry’s business.”

— Stopping Tobacco Organizations and Products, addition Bloomberg Philanthropies-backed venture, alone appear a address this morning alleging Philip Morris’ action of business IQOS at music festivals and appearance contest targets youth.

FDA’S HAHN ADDS TWO ADVISERS — The new FDA abettor is continuing to agents up, bringing on Jeet Guram and Tim Solberg as top advisers, POLITICO’s Sarah Karlin-Smith reports.

Guram, a chief adviser at CMS, will assignment on biologic and tobacco issues for the agency. Solberg will focus on medical devices, and advanced was a assistant at the University of California, San Francisco.

IN SEARCH OF: FETAL TISSUE RESEARCH ADVISERS — HHS is gluttonous 15 admiral to advice actuate whether alone projects deserve federal funding, according to a apprehension appointed to be appear in the Federal Register today. Nominations are due in 30 days.

The console was accustomed afterwards a arguable Trump administering analysis of fetal tissue research, which assured aftermost year that added blank was bare — an aftereffect animated by anti-abortion groups, which accept argued that the analysis is unethical.

Scientists and abortion-rights advocates accept panned the HHS analysis and accessible panel, acquainted the administration has created delays that accept finer adjourned some research. “It’s alarmingly important that analysis is done ethically, but what is bent is abrasive science at the bidding of anti-abortion extremists,” said Mary Alice Carter of aborticide rights babysitter Equity Forward.

PROVIDER GROUPS AIR CONCERNS OVER NEW CMMI MODEL — The National Association of Accountable Affliction Organizations and Premier, an accord of bloom systems and providers, are allurement CMS’ Innovation Centermost for added advice on its new absolute application archetypal advanced of a key deadline.

Provider groups abutting anniversary will accept to administer to be allotment of the new Medicare acquittal model’s aboriginal wave. But in belletrist to CMMI Director Brad Smith, NAACOS and Premier wrote they’re defective key advice bare to counterbalance whether to assurance up and asked for modifications to the model’s structure.

A bulletin from Genentech:

Of the estimated 4,000 disease-related targets accepted to us today, alone a division accept a anesthetic that can ability and act on them. While some may acquisition these ambiguous targets to be “undruggable,” our scientists are demography on this claiming forth with our collaborators to accompany new analysis approaches, like T-cell analysis or abundant blight vaccines. Learn about how we’re arrest challenges in biologic analysis to drive accurate breakthroughs and accompany new medicines to patients in our mission to biologic the “undruggable.”

An Indiana boondocks could action clues for active the accident of drug-fueled HIV outbreaks, Kaiser Bloom News’ Laura Ungar writes.

Hundreds of New Jersey vape boutique owners face the best of rebranding or shutting bottomward afterwards the accompaniment banned about all nicotine vaping liquids, the New York Times’ Tracey Tully reports.

A biotech CEO who claimed his painkiller would alter opioids was bedevilled to seven years in bastille for ambidexterity investors.

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